Unfolded protein response at the cross roads of tumourigenesis, oxygen sensing and drug resistance in clear cell renal cell carcinoma

Yew Hwang Chee; Afshin Samali; Claire M Robinson

doi:10.1016/j.bbcan.2022.188814

Unfolded protein response at the cross roads of tumourigenesis, oxygen sensing and drug resistance in clear cell renal cell carcinoma

Biochim Biophys Acta Rev Cancer. 2022 Nov;1877(6):188814. doi: 10.1016/j.bbcan.2022.188814. Epub 2022 Oct 3.

Authors

Yew Hwang Chee¹, Afshin Samali¹, Claire M Robinson²

Affiliations

¹ Apoptosis Research Centre, School of Biological and Chemical Sciences, University of Galway, Ireland.
² Apoptosis Research Centre, School of Biological and Chemical Sciences, University of Galway, Ireland. Electronic address: claire.robinson@universityofgalway.ie.

PMID: 36195277
DOI: 10.1016/j.bbcan.2022.188814

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Despite therapeutic advances, long term survival in patients diagnosed with advanced disease is low. Efforts to understand the mechanisms promoting disease progression will likely produce novel therapeutic targets. The unfolded protein response (UPR) is activated when unfolded protein accumulates in the endoplasmic reticulum (ER) upon cellular stress. Constitutive UPR activation is a characteristic of many malignancies. We discuss the accumulating evidence that describes a role for the UPR in ccRCC. Studies focused on UPR signalling may provide compelling avenues for therapeutic intervention in the future.

Keywords: Clear cell renal cell carcinoma (ccRCC); Tumourigenesis; Unfolded protein response (UPR).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinogenesis
Carcinoma, Renal Cell* / drug therapy
Carcinoma, Renal Cell* / genetics
Cell Transformation, Neoplastic
Drug Resistance
Endoplasmic Reticulum Stress / physiology
Humans
Kidney Neoplasms* / drug therapy
Kidney Neoplasms* / genetics
Oxygen
Unfolded Protein Response

Substances

Oxygen