T-bet+ B cells exacerbate obesity-related metabolic disease

Saad Khan; Daniel A Winer

doi:10.1016/j.it.2022.09.011

T-bet⁺ B cells exacerbate obesity-related metabolic disease

Trends Immunol. 2022 Nov;43(11):855-857. doi: 10.1016/j.it.2022.09.011. Epub 2022 Oct 7.

Authors

Saad Khan¹, Daniel A Winer²

Affiliations

¹ Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada.
² Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, ON M5S 1A8, Canada; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address: dwiner@buckinstitute.org.

PMID: 36216716
DOI: 10.1016/j.it.2022.09.011

Abstract

B cells are associated with the development of obesity-associated metabolic disease. Recently, Hägglöf, Vanz, et al. identified a novel obesity-related subset of B cells that are demarcated by the transcription factor T-bet and their pathogenic ability to worsen metabolic disease outcomes.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

B-Lymphocytes / metabolism
Humans
Metabolic Diseases* / metabolism
Obesity
T-Box Domain Proteins* / metabolism

Substances

T-Box Domain Proteins

Grants and funding

R01 DK128435/DK/NIDDK NIH HHS/United States