Neural crest cells hijack pluripotent stem cell factors to realize their developmental potential

Salome Stierli; Lukas Sommer

doi:10.1016/j.devcel.2022.09.010

Neural crest cells hijack pluripotent stem cell factors to realize their developmental potential

Dev Cell. 2022 Oct 10;57(19):2249-2250. doi: 10.1016/j.devcel.2022.09.010.

Authors

Salome Stierli¹, Lukas Sommer²

Affiliations

¹ Institute of Anatomy, University of Zurich, Zurich, Switzerland.
² Institute of Anatomy, University of Zurich, Zurich, Switzerland. Electronic address: lukas.sommer@anatomy.uzh.ch.

PMID: 36220078
DOI: 10.1016/j.devcel.2022.09.010

Abstract

Neural crest cells arise in the neurectoderm of vertebrate embryos, but their developmental potential goes way beyond neurectodermal derivatives. In this issue of Developmental Cell, Hovland et al. reveal that neural crest cells re-employ embryonic stem cell factors in combination with specific transcription factors to enable their broad potential.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation
Gene Expression Regulation, Developmental
Neural Crest*
Pluripotent Stem Cells*
Stem Cell Factor
Transcription Factors
Vertebrates

Substances

Stem Cell Factor
Transcription Factors