Metabolic communication in the tumour-immune microenvironment

Nat Cell Biol. 2022 Nov;24(11):1574-1583. doi: 10.1038/s41556-022-01002-x. Epub 2022 Oct 13.

Abstract

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission following immunotherapy. Metabolic communication between cancer cells and their neighbouring immune cells could determine the amplitude and type of immune responses, highlighting a potential involvement of metabolic crosstalk in immune surveillance and escape. In this Review, we explore tumour-immune metabolic crosstalk and discuss potential nutrient-limiting strategies that favour anti-tumour immune responses.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Immunity
  • Immunotherapy
  • Neoplasms* / metabolism
  • Tumor Microenvironment*