The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial

Maria Papageorgiou; Emmanuel Biver; Julie Mareschal; Nicholas Edward Phillips; Alexandra Hemmer; Emma Biolley; Nathalie Schwab; Emily N C Manoogian; Elena Gonzalez Rodriguez; Daniel Aeberli; Didier Hans; Caroline Pot; Satchidananda Panda; Nicolas Rodondi; Serge L Ferrari; Tinh-Hai Collet

doi:10.1002/oby.23577

The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial

Obesity (Silver Spring). 2023 Feb;31 Suppl 1(Suppl 1):85-95. doi: 10.1002/oby.23577. Epub 2022 Oct 14.

Authors

Maria Papageorgiou¹, Emmanuel Biver¹, Julie Mareschal², Nicholas Edward Phillips^{2

3}, Alexandra Hemmer², Emma Biolley², Nathalie Schwab^{4

5}, Emily N C Manoogian⁶, Elena Gonzalez Rodriguez⁷, Daniel Aeberli⁸, Didier Hans⁷, Caroline Pot⁹, Satchidananda Panda⁶, Nicolas Rodondi^{4

5}, Serge L Ferrari¹, Tinh-Hai Collet^{2

10}

Affiliations

¹ Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
² Nutrition Unit, Service of Endocrinology, Diabetes, Nutrition and Therapeutic Education, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
³ Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁴ Department of General Internal Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
⁵ Institute of Primary Health Care, University of Bern, Bern, Switzerland.
⁶ Salk Institute for Biological Sciences, La Jolla, California, USA.
⁷ Interdisciplinary Center for Bone Diseases, Service of Rheumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
⁸ Department of Rheumatology and Immunology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
⁹ Division of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
¹⁰ Diabetes Centre, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Abstract

Objective: This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.

Methods: Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.

Results: In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.

Conclusions: TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Absorptiometry, Photon
Adult
Bone Density* / physiology
Bone and Bones*
Female
Humans
Male
Middle Aged
Weight Loss

Substances

Procollagen Type I