Overview of DNA damage and double-strand breaks

Abstract

DNA is under a variety of assaults. As a result, different damages accumulate on DNA. These include base changes, single-strand breaks and double-strand breaks. In this volume and also briefly in the following volume, we discuss DNA damage and double-strand breaks. In particular, we focus on double-strand breaks. We discuss types of double-strand breaks as well as methods to detect them. We also discuss how DNA breaks are formed.

Keywords: Clustered damage; DNA damage; Detection of double-strand breaks; Direct and indirect effect; Double-strand breaks; Single-strand breaks.