Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseases

Megan M Braun; Luigi Puglielli

doi:10.3389/fncel.2022.1031153

Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseases

Front Cell Neurosci. 2022 Oct 20:16:1031153. doi: 10.3389/fncel.2022.1031153. eCollection 2022.

Authors

Megan M Braun^{1

2

3}, Luigi Puglielli^{1

2

3

4

5}

Affiliations

¹ Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
² Waisman Center, University of Wisconsin-Madison, Madison, WI, United States.
³ Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, United States.
⁴ Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
⁵ Geriatric Research Education Clinical Center, Veterans Affairs Medical Center, Madison, WI, United States.

Abstract

The selective degradation of mitochondria through mitophagy is a crucial process for maintaining mitochondrial function and cellular health. Mitophagy is a specialized form of selective autophagy that uses unique machinery to recognize and target damaged mitochondria for mitophagosome- and lysosome-dependent degradation. This process is particularly important in cells with high metabolic activity like neurons, and the accumulation of defective mitochondria is a common feature among neurodegenerative disorders. Here, we describe essential steps involved in the induction and progression of mitophagy, and then highlight the various mechanisms that specifically contribute to defective mitophagy in highly prevalent neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis.

Keywords: Alzheimer’s disease; Huntington’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; mitochondria; mitochondrial dysfunction; mitophagy; neurodegeneration.

Publication types

Review

Abstract

Publication types

Grants and funding