A gut-retching discovery

Jane Y Chen; Richard D Palmiter

doi:10.1016/j.cell.2022.10.015

A gut-retching discovery

Cell. 2022 Nov 10;185(23):4249-4251. doi: 10.1016/j.cell.2022.10.015.

Authors

Jane Y Chen¹, Richard D Palmiter²

Affiliations

¹ Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98199, USA.
² Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98199, USA. Electronic address: palmiter@uw.edu.

PMID: 36368302
DOI: 10.1016/j.cell.2022.10.015

Abstract

In this issue of Cell, Xie et al. identify a gut-to-brain pathway that triggers retching after toxic food ingestion or emetic agent administration. Their results shed light on how peripheral signals reach the brain to orchestrate appropriate behavioral responses and facilitate learning to prevent repeated ingestion of harmful substances.

Publication types

Comment

MeSH terms

Humans
Intestines*
Vomiting* / prevention & control