Acetyl-CoA, protein acetylation, and liver cancer

Zhengming Wu; Kun-Liang Guan

doi:10.1016/j.molcel.2022.10.015

Acetyl-CoA, protein acetylation, and liver cancer

Mol Cell. 2022 Nov 17;82(22):4196-4198. doi: 10.1016/j.molcel.2022.10.015.

Authors

Zhengming Wu¹, Kun-Liang Guan²

Affiliations

¹ Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
² Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. Electronic address: kuguan@ucsd.edu.

PMID: 36400006
DOI: 10.1016/j.molcel.2022.10.015

Abstract

Using multi-omics approaches, Park et al. show that reduced cellular acetyl-CoA and protein hypoacetylation promote liver cancer growth and dedifferentiation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Acetyl Coenzyme A / metabolism
Acetylation
Histones* / metabolism
Humans
Liver Neoplasms* / genetics
Protein Processing, Post-Translational

Substances

Acetyl Coenzyme A
Histones