α-Ketoglutaramate-A key metabolite contributing to glutamine addiction in cancer cells

Arthur J L Cooper; Thambi Dorai; John T Pinto; Travis T Denton

doi:10.3389/fmed.2022.1035335

α-Ketoglutaramate-A key metabolite contributing to glutamine addiction in cancer cells

Front Med (Lausanne). 2022 Nov 4:13:1035335. doi: 10.3389/fmed.2022.1035335. eCollection 2022.

Authors

Arthur J L Cooper¹, Thambi Dorai^{1

2}, John T Pinto¹, Travis T Denton^{3

4

5}

Affiliations

¹ Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, United States.
² Department of Urology, New York Medical College, Valhalla, NY, United States.
³ Department Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University Health Sciences Spokane, Spokane, WA, United States.
⁴ Department of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University Health Sciences Spokane, Spokane, WA, United States.
⁵ Steve Gleason Institute for Neuroscience, Washington State University Health Sciences Spokane, Spokane, WA, United States.

No abstract available

Keywords: glutaminase II pathway; glutamine transaminase K; glutamine transaminases; methionine salvage pathway; nitrogen homeostasis; α-ketoglutaramate; α-ketoglutarate; ω-amidase.