Cell cycle: Making waves to coordinate the entry into mitosis

Zachary M Wilmott; Jordan W Raff

doi:10.1016/j.cub.2022.10.030

Cell cycle: Making waves to coordinate the entry into mitosis

Curr Biol. 2022 Nov 21;32(22):R1262-R1264. doi: 10.1016/j.cub.2022.10.030.

Authors

Zachary M Wilmott¹, Jordan W Raff²

Affiliations

¹ Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
² Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. Electronic address: jordan.raff@path.ox.ac.uk.

PMID: 36413966
DOI: 10.1016/j.cub.2022.10.030

Abstract

How do very large cells coordinate their entry into mitosis? A new study shows that the bistability of the Cdk/Cyclin system allows cells to generate either 'trigger waves' or 'sweep waves' that drive cells into mitosis in different ways with distinct consequences.

Publication types

Comment

MeSH terms

Cell Cycle
Cell Cycle Checkpoints
Cell Cycle Proteins / genetics
Cyclins*
Mitosis*

Substances

Cyclins
Cell Cycle Proteins