IRF2 integrates inflammatory signals to balance T cell exhaustion

Amania A Sheikh; Daniel T Utzschneider

doi:10.1016/j.immuni.2022.11.010

IRF2 integrates inflammatory signals to balance T cell exhaustion

Immunity. 2022 Dec 13;55(12):2225-2227. doi: 10.1016/j.immuni.2022.11.010.

Authors

Amania A Sheikh¹, Daniel T Utzschneider²

Affiliations

¹ Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
² Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia. Electronic address: daniel.utzschneider@unimelb.edu.au.

PMID: 36516816
DOI: 10.1016/j.immuni.2022.11.010

Abstract

The transcription factor interferon regulatory factor 2 (IRF2) translates interferon signaling to regulate T cells. In this issue of Immunity, Lukhele et al. identify IRF2 in tumor-infiltrating T cells as a sensor for extrinsic signals that drives an exhaustion program.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gene Expression Regulation
Interferon Regulatory Factor-2 / genetics
Interferon Regulatory Factor-2 / metabolism
T-Cell Exhaustion*
Transcription Factors*

Substances

Interferon Regulatory Factor-2
Transcription Factors