Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity

Kaili Xue; Dongmei Wu; Yifu Qiu

doi:10.1016/j.tcb.2022.11.008

Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity

Trends Cell Biol. 2023 Mar;33(3):182-184. doi: 10.1016/j.tcb.2022.11.008. Epub 2022 Dec 13.

Authors

Kaili Xue¹, Dongmei Wu², Yifu Qiu³

Affiliations

¹ Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
² Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
³ Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: yifu.qiu@pku.edu.cn.

PMID: 36517314
DOI: 10.1016/j.tcb.2022.11.008

Abstract

The mitochondrial calcium uniporter (MCU) controls mitochondrial bioenergetics, and its activity varies greatly between tissues. Here, we highlight a recently identified MCU-EMRE-UCP1 complex, named thermoporter, in the adaptive thermogenesis of brown adipose tissue (BAT). The thermoporter enhances MCU activity to promote thermogenic metabolism, demonstrating a BAT-specific regulation for MCU activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcium / metabolism
Calcium Channels* / metabolism
Cell Membrane / metabolism
Humans
Mitochondria* / metabolism

Substances

mitochondrial calcium uniporter
Calcium Channels
Calcium