FASTK family of genes linked to cancer

Abilasha Ramasubramanian; A Paramasivam; Pratibha Ramani

doi:10.6026/97320630018206

FASTK family of genes linked to cancer

Bioinformation. 2022 Mar 31;18(3):206-213. doi: 10.6026/97320630018206. eCollection 2022.

Authors

Abilasha Ramasubramanian¹, A Paramasivam², Pratibha Ramani¹

Affiliations

¹ Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Poonamallee High Road, Chennai, Tamilnadu - 600077, India.
² Department of Dental Research Cell- Blue Lab, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Poonamallee High Road, Chennai, Tamilnadu - 600077, India.

Abstract

Fas Activated Serine/Threonine Kinase (FASTK) family is a protein family encoded in the nuclear genome that spans the mitochondria and executes numerous functions, and consists of FASTK, the founding member along with 5 homologous proteins FASTKD1-5. Up regulation of FASTK family members have not only been implicated in tumour progression and invasion but also in increased resistance to chemotherapy proven by their knockdown leading to increased sensitivity to drugs. Thus, this review reports the implication of FASTK proteins in cancer and hence provides a scope to emphasise the role of these proteins in Oral Cancer.

Keywords: FAST; FASTK family; cancer; mitochondrial dysfunction.