The molecular evolution of spermatogenesis across mammals

Nature. 2023 Jan;613(7943):308-316. doi: 10.1038/s41586-022-05547-7. Epub 2022 Dec 21.

Abstract

The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals1-6, probably owing to the evolutionary pressure on males to be reproductively successful7. However, the molecular evolution of individual spermatogenic cell types across mammals remains largely uncharacterized. Here we report evolutionary analyses of single-nucleus transcriptome data for testes from 11 species that cover the three main mammalian lineages (eutherians, marsupials and monotremes) and birds (the evolutionary outgroup), and include seven primates. We find that the rapid evolution of the testis was driven by accelerated fixation rates of gene expression changes, amino acid substitutions and new genes in late spermatogenic stages, probably facilitated by reduced pleiotropic constraints, haploid selection and transcriptionally permissive chromatin. We identify temporal expression changes of individual genes across species and conserved expression programs controlling ancestral spermatogenic processes. Genes predominantly expressed in spermatogonia (germ cells fuelling spermatogenesis) and Sertoli (somatic support) cells accumulated on X chromosomes during evolution, presumably owing to male-beneficial selective forces. Further work identified transcriptomal differences between X- and Y-bearing spermatids and uncovered that meiotic sex-chromosome inactivation (MSCI) also occurs in monotremes and hence is common to mammalian sex-chromosome systems. Thus, the mechanism of meiotic silencing of unsynapsed chromatin, which underlies MSCI, is an ancestral mammalian feature. Our study illuminates the molecular evolution of spermatogenesis and associated selective forces, and provides a resource for investigating the biology of the testis across mammals.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Birds / genetics
  • Chromatin / genetics
  • Dosage Compensation, Genetic
  • Evolution, Molecular*
  • Gene Expression Regulation
  • Gene Silencing
  • Male
  • Mammals* / genetics
  • Meiosis / genetics
  • Primates / genetics
  • Sertoli Cells / cytology
  • Single-Cell Analysis
  • Spermatogenesis* / genetics
  • Spermatogonia / cytology
  • Testis* / cytology
  • Transcriptome
  • X Chromosome / genetics
  • Y Chromosome / genetics

Substances

  • Chromatin