Urinary Citrate Is Associated with Kidney Outcomes in Early Polycystic Kidney Disease

Daniel Ribeiro Rocha; Laixi Xue; Hiago Murilo Gomes Sousa; Ana Christina Carvalho Matos; Ewout J Hoorn; Mahdi Salih; Ita Pfeferman Heilberg

doi:10.34067/KID.0004772022

Urinary Citrate Is Associated with Kidney Outcomes in Early Polycystic Kidney Disease

Kidney360. 2022 Oct 17;3(12):2110-2115. doi: 10.34067/KID.0004772022. eCollection 2022 Dec 29.

Authors

Daniel Ribeiro Rocha¹, Laixi Xue², Hiago Murilo Gomes Sousa¹, Ana Christina Carvalho Matos¹, Ewout J Hoorn², Mahdi Salih², Ita Pfeferman Heilberg¹

Affiliations

¹ Division of Nephrology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
² Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

Low urinary citrate and crystal deposition accelerated cystogenesis in an experimental model of polycystic kidney disease (PKD).Hypocitraturia, frequently observed in patients with autosomal dominant PKD (ADPKD) could contribute to disease progression.Present findings suggest lower urinary citrate in early PKD was associated with faster eGFR decline and worse kidney survival.

Keywords: ADPKD; CKD; cystic kidney disease; eGFR; polycystic kidney disease; urinary citrate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcinosis* / complications
Citric Acid
Disease Progression
Humans
Kidney
Polycystic Kidney, Autosomal Dominant* / complications

Substances

Citric Acid