The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related

J Hoppe; L Schumacher; W Eichner; H A Weich

doi:10.1016/0014-5793(87)80297-1

The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related

FEBS Lett. 1987 Nov 2;223(2):243-6. doi: 10.1016/0014-5793(87)80297-1.

Authors

J Hoppe¹, L Schumacher, W Eichner, H A Weich

Affiliation

¹ Department of Cytogenetics, GBF-Gesellschaft für Biotechnologische Forschung mbH., Braunschweig, FRG.

PMID: 3666150
DOI: 10.1016/0014-5793(87)80297-1

Abstract

A cDNA clone of about 2300 base pairs was prepared from the human osteosarcoma cell line U-2 OS by hybridization with a 22-mer oligonucleotide complementary to the NH2-terminus of PDGF-A. Restriction and sequence analysis showed that this clone contains the entire coding region for PDGF-A and a long 3'-untranslated region which is only distantly related to that in the mRNA of PDGF-B.

MeSH terms

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Humans
Molecular Sequence Data
Molecular Weight
Platelet-Derived Growth Factor / genetics*
Protein Biosynthesis
RNA, Messenger / genetics
Tumor Cells, Cultured

Substances

Platelet-Derived Growth Factor
RNA, Messenger

Associated data

GENBANK/X06374