Application of nanomedicine in radiotherapy sensitization

Xiaoyu Song; Zhenkun Sun; Li Li; Lu Zhou; Shuanghu Yuan

doi:10.3389/fonc.2023.1088878

Application of nanomedicine in radiotherapy sensitization

Front Oncol. 2023 Feb 15:13:1088878. doi: 10.3389/fonc.2023.1088878. eCollection 2023.

Authors

Xiaoyu Song^{1

2}, Zhenkun Sun³, Li Li², Lu Zhou³, Shuanghu Yuan^{2

4

5}

Affiliations

¹ School of Clinical Medicine, Weifang Medical University, Weifang, China.
² Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong First Medical University, Jinan, China.
³ Shunde Hospital, Guangzhou University of Traditional Chinese Medicine, Foshan, Guangdong, China.
⁴ Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
⁵ Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Radiation therapy is an important component of cancer treatment. As research in radiotherapy techniques advances, new methods to enhance tumor response to radiation need to be on the agenda to enable enhanced radiation therapy at low radiation doses. With the rapid development of nanotechnology and nanomedicine, the use of nanomaterials as radiosensitizers to enhance radiation response and overcome radiation resistance has attracted great interest. The rapid development and application of emerging nanomaterials in the biomedical field offers good opportunities to improve the efficacy of radiotherapy, which helps to promote the development of radiation therapy and will be applied in clinical practice in the near future. In this paper, we discuss the main types of nano-radiosensitizers and explore their sensitization mechanisms at the tissue level, cellular level and even molecular biology and genetic level, and analyze the current status of promising nano-radiosensitizers and provide an outlook on their future development and applications.

Keywords: mechanism; nano-radiosensitizers; nanomedicine; radiosensitizers; radiotherapy; therapeutics.

Publication types

Review

Grants and funding

This study was partially supported by the National Natural Science Foundation of China (grant No. NSFC81872475 and NSFC82073345) and Jinan Clinical Medicine Science and Technology Innovation Plan (202019060) to SY.