Getting in on the action: New tools to see SARS-CoV-2 infect a cell

Scott B Hansen; Zixuan Yuan

doi:10.1016/j.chembiol.2023.02.010

Getting in on the action: New tools to see SARS-CoV-2 infect a cell

Cell Chem Biol. 2023 Mar 16;30(3):233-234. doi: 10.1016/j.chembiol.2023.02.010.

Authors

Scott B Hansen¹, Zixuan Yuan²

Affiliations

¹ Department of Molecular Medicine, UF Scripps, Jupiter, FL 33458, USA; Department of Neuroscience, UF Scripps, Jupiter, FL 33458, USA. Electronic address: hansen.scott@ufl.edu.
² Department of Molecular Medicine, UF Scripps, Jupiter, FL 33458, USA; Department of Neuroscience, UF Scripps, Jupiter, FL 33458, USA; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL 33458, USA.

Abstract

In this issue of Cell Chemical Biology, Miao et al. develop probes for live cell tracking of SARS-CoV-2. The probes reveal the endocytic pathway for viral entry. Unexpectedly, the antiviral compound BafA1 traps the virus on the cell surface, highlighting the power of super-resolution imaging in live cells.

Publication types

Comment

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / pharmacology
COVID-19*
Humans
SARS-CoV-2*
Virus Internalization

Substances

Antiviral Agents

Grants and funding

R01 NS112534/NS/NINDS NIH HHS/United States