A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade

Carolina Mangana; Barbara B Maier

doi:10.1016/j.ccell.2023.02.020

A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade

Cancer Cell. 2023 Apr 10;41(4):653-655. doi: 10.1016/j.ccell.2023.02.020. Epub 2023 Mar 30.

Authors

Carolina Mangana¹, Barbara B Maier²

Affiliations

¹ CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.
² CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria. Electronic address: bmaier@cemm.oeaw.ac.at.

PMID: 37001525
DOI: 10.1016/j.ccell.2023.02.020

Abstract

Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely understood. In this issue, Pai et al. present a temporally and spatially resolved differentiation map of tumor-directed T cells in patients with lung cancer on PD-1 blockade.

Publication types

Comment

MeSH terms

B7-H1 Antigen
CD8-Positive T-Lymphocytes
Humans
Immune Checkpoint Inhibitors* / therapeutic use
Lung Neoplasms* / drug therapy
T-Cell Exhaustion
T-Lymphocytes

Substances

Immune Checkpoint Inhibitors
B7-H1 Antigen