Challenges and opportunities for modeling aging and cancer

Olga Anczuków; Susie Airhart; Jeffrey H Chuang; Lisa M Coussens; George A Kuchel; Ron Korstanje; Sheng Li; Anna Lisa Lucido; Sandra S McAllister; Katerina Politi; Kornelia Polyak; Timothy Ratliff; Gary Ren; Jennifer J Trowbridge; Duygu Ucar; Karolina Palucka

doi:10.1016/j.ccell.2023.03.006

Challenges and opportunities for modeling aging and cancer

Cancer Cell. 2023 Apr 10;41(4):641-645. doi: 10.1016/j.ccell.2023.03.006. Epub 2023 Mar 30.

Authors

Olga Anczuków¹, Susie Airhart², Jeffrey H Chuang³, Lisa M Coussens⁴, George A Kuchel⁵, Ron Korstanje², Sheng Li³, Anna Lisa Lucido³, Sandra S McAllister⁶, Katerina Politi⁷, Kornelia Polyak⁸, Timothy Ratliff⁹, Gary Ren², Jennifer J Trowbridge², Duygu Ucar³, Karolina Palucka¹⁰

Affiliations

¹ The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address: olga.anczukow@jax.org.
² The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.
³ The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
⁴ Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
⁵ UConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT, USA.
⁶ Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
⁷ Departments of Pathology, and Medicine (Section of Medical Oncology), Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA.
⁸ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA; The Ludwig Center at Harvard, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
⁹ Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
¹⁰ The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address: karolina.palucka@jax.org.

Abstract

Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aging*
Animals
Disease Models, Animal
Mice
Neoplasms* / genetics
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding