Toxicity of Pluronic F-68

Toxicol Lett. 1986 Mar;30(3):203-7. doi: 10.1016/0378-4274(86)90156-6.

Abstract

The toxicity of Pluronic F-68, a non-ionic polyol, was studied in the rat when administered intravenously for one month in daily doses of 0, 10, 20, 50, 100, 200, 500 and 1000 mg/kg. Pluronic F-68 induced pulmonary foam cells at the dose levels of 500 and 1000 mg/kg and slight focal degenerative changes in the proximal tubules of the kidneys at the dose levels of 100, 200, 500 and 1000 mg/kg. The cytoplasm of the pulmonary foam cells contained lipid droplets, phospholipids being the most essential constituent. The results indicate that Pluronic F-68 is able to induce phospholipidosis in the rat. Only drugs have so far been reported to cause this condition in the rat.

MeSH terms

  • Animals
  • Female
  • Foam Cells / drug effects
  • Kidney / drug effects*
  • Kidney / metabolism
  • Kidney / pathology
  • Lipidoses / chemically induced
  • Lipidoses / pathology
  • Lung / drug effects*
  • Lung / metabolism
  • Lung / pathology
  • Phospholipids / metabolism
  • Poloxalene / toxicity*
  • Polyethylene Glycols / toxicity*
  • Rats

Substances

  • Phospholipids
  • Polyethylene Glycols
  • Poloxalene