Cystic kidney diseases in children

J De Groof; A Dachy; L Breysem; D Mekahli

doi:10.1016/j.arcped.2023.02.005

Cystic kidney diseases in children

Arch Pediatr. 2023 May;30(4):240-246. doi: 10.1016/j.arcped.2023.02.005. Epub 2023 Apr 14.

Authors

J De Groof¹, A Dachy², L Breysem³, D Mekahli⁴

Affiliations

¹ Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium.
² PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; Department of Pediatrics, ULiège Academic Hospital, Liège, Belgium.
³ Department of Pediatric Radiology, University Hospitals Leuven, Leuven, Belgium.
⁴ Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium; PKD Research Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. Electronic address: djalila.mekahli@uzleuven.be.

PMID: 37062654
DOI: 10.1016/j.arcped.2023.02.005

Abstract

Cystic kidney disease comprises a broad group of heterogeneous diseases, which differ greatly in age at onset, disease manifestation, systemic involvement, disease progression, and long-term prognosis. As our understanding of these diseases continues to evolve and new treatment strategies continue to emerge, correctly differentiating and diagnosing these diseases becomes increasingly important. In this review, we aim to highlight the key features of the most relevant cystic kidney diseases, underscore important diagnostic characteristics of each disease, and present specific management options if applicable.

Keywords: ADPKD; ARPDK; Bardet–Biedl syndrome; Cystic dysplasia; HNF1-beta; Kidney cyst; Multicystic dysplastic kidney; Nephronophthisis; Simple kidney cyst; tuberous sclerosis complex.

Publication types

Review

MeSH terms

Child
Disease Progression
Humans
Kidney
Kidney Diseases, Cystic* / diagnosis
Kidney Diseases, Cystic* / therapy
Prognosis