The therapeutic efficacy of Bulgarian antidepressants (adepren, linamiphen, and emovit) was assessed. The results showed that adepren, due to the predominance in the spectrum of its action of a stimulating effect over a sedative one, proved the least effective in anxiety depressions and most effective in inhibitory, asthenic and adynamic depressions. Linamiphen had a more marked antidepressive and stimulating action and was effective in inhibitory depressions of different genesis but the incidence of side effects (fast pulse, elevated blood pressure) was rather high. Emovit was characterized by the predominance of sedative versus stimulating action and, hence, it was most effective in anxiety, asthenic-anxiety, depressive-paranoid and hypochondriac depressions, showing no effect in inhibitory depressions. It did not lead to exacerbation of any other, in particular paranoid, symptomatology.