Amino-functionalized Al-MOF modulated TpTt-COF with dual-emission for fluorescent and optosmart detecting tetracycline in food samples

Food Chem. 2023 Nov 1:425:136476. doi: 10.1016/j.foodchem.2023.136476. Epub 2023 May 30.

Abstract

Tetracycline residues in animal-derived food pose serious harm to human health, making it demanded to develop simple and sensitive method for detecting tetracycline. Herein, a dual-emission synchronous response fluorescence probe is reported based on amino-functionalized Al-MOF modulated TpTt-COF (donate as NMT). NMT exhibits excellent dual-emission at 455 and 575 nm under single excitation. Tetracycline is sensitively detected through quenching the dual-emission of NMT. NMT specifically recognizes tetracycline through intermolecular hydrogen bonding between -OH/-NH2 of tetracycline and deprotonated O-/-NH-/CN of NMT. A calibration curve is built between the fluorescence ratio and the tetracycline concentration with a detection limit of 0.014 μmol/L. NMT is employed to detect tetracycline in milk, pork and chicken, and displays satisfactory recoveries of 94.39-105.67%, respectively. The optosmart sensor based on NMT and smartphone has been constructed for visually detecting tetracycline. This method provides routes to construct MOF-COF fluorescence probes and has good prospects in food analysis.

Keywords: Antibiotic residues; Covalent-organic framework; Fluorescence detection; Food safety; Metal–organic framework; Visual analysis.

MeSH terms

  • Animals
  • Anti-Bacterial Agents* / chemistry
  • Fluorescence
  • Fluorescent Dyes
  • Heterocyclic Compounds*
  • Humans
  • Limit of Detection
  • Spectrometry, Fluorescence / methods
  • Tetracycline / analysis

Substances

  • Anti-Bacterial Agents
  • Tetracycline
  • Fluorescent Dyes
  • Heterocyclic Compounds