The effect of tetrahydrofolate on tetrahydrobiopterin metabolism

J Ment Defic Res. 1986 Jun:30 ( Pt 2):179-83. doi: 10.1111/j.1365-2788.1986.tb01310.x.

Abstract

5-Methyltetrahydrofolate and vitamin B12 appear to be required for the biosynthesis of tetrahydrobiopterin. A deficiency of either could be sufficient to bring about neurological change which can be corrected by reversing the deficiency. Patients with senile dementia could possibly be benefited by the administration of 5-methyltetrahydrofolate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / metabolism*
  • Animals
  • Biopterins / analogs & derivatives
  • Biopterins / biosynthesis*
  • Child, Preschool
  • Humans
  • In Vitro Techniques
  • Infant
  • Male
  • Middle Aged
  • Pteridines / biosynthesis*
  • Rats
  • Rats, Inbred Strains
  • Temporal Lobe / metabolism
  • Tetrahydrofolates / pharmacology*
  • Vitamin B 12 / pharmacology

Substances

  • Pteridines
  • Tetrahydrofolates
  • Biopterins
  • sapropterin
  • Vitamin B 12
  • 5-methyltetrahydrofolate