NLRP12 drives PANoptosis in response to heme

Fiona D R Henkel; Luke A J O'Neill

doi:10.1016/j.it.2023.06.008

NLRP12 drives PANoptosis in response to heme

Trends Immunol. 2023 Aug;44(8):574-576. doi: 10.1016/j.it.2023.06.008. Epub 2023 Jul 7.

Authors

Fiona D R Henkel¹, Luke A J O'Neill²

Affiliations

¹ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
² School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Electronic address: laoneill@tcd.ie.

PMID: 37423881
DOI: 10.1016/j.it.2023.06.008

Abstract

PANoptosomes are large cell death-inducing complexes that drive a type of cell death called PANoptosis during infection and inflammation. Sundaram and colleagues recently identified NLRP12 as a PANoptosome that induces PANoptosis in response to heme, TNF, and pathogen-associated molecular patterns (PAMPs), indicating a role for NLRP12 in hemolytic and inflammatory diseases.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Heme*
Humans
Inflammation
Intracellular Signaling Peptides and Proteins*

Substances

Intracellular Signaling Peptides and Proteins
Heme
NLRP12 protein, human