Axonal Transport Defects in Retinal Ganglion Cell Diseases

Iskalen Cansu Topcu Okan; Fatma Ozdemir; Cavit Agca

doi:10.1007/978-3-031-27681-1_32

Axonal Transport Defects in Retinal Ganglion Cell Diseases

Adv Exp Med Biol. 2023:1415:223-227. doi: 10.1007/978-3-031-27681-1_32.

Authors

Iskalen Cansu Topcu Okan¹, Fatma Ozdemir¹, Cavit Agca^{2

3}

Affiliations

¹ Molecular Biology, Genetics and Bioengineering Program, Sabanci University, Istanbul, Turkey.
² Molecular Biology, Genetics and Bioengineering Program, Sabanci University, Istanbul, Turkey. cavit.agca@sabanciuniv.edu.
³ Nanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul, Turkey. cavit.agca@sabanciuniv.edu.

PMID: 37440037
DOI: 10.1007/978-3-031-27681-1_32

Abstract

For the survival and maintenance of retinal ganglion cells (RGCs), axonal transportation is fundamental. Axonal transportation defects can cause severe neuropathies leading to neuronal loss. Axonal transport defects usually precede axonal degeneration and RGC loss in disease models. To date, the main causes of axonal transport defects have not been fully understood. Therefore, elucidation of the mechanisms that lead to transport defects will help us to develop novel therapeutic targets and early diagnostic tools. In this review, we provide an overview of optic neuropathies and axonal degeneration with a focus on axonal transport.

Keywords: Axonal degeneration; Axonal transport; Glaucoma; Mitochondria; OPA1.

Publication types

Review

MeSH terms

Animals
Axonal Transport / physiology
Axons / metabolism
Disease Models, Animal
Humans
Optic Nerve Diseases*
Retinal Ganglion Cells* / physiology