Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer

Taylar Hammond; Julien Sage

doi:10.1101/cshperspect.a041383

Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer

Cold Spring Harb Perspect Med. 2023 Jul 17;13(12):a041383. doi: 10.1101/cshperspect.a041383. Online ahead of print.

Authors

Taylar Hammond^{1

2}, Julien Sage^{3

4}

Affiliations

¹ Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
² Department of Biology, and Stanford University, Stanford, California 94305, USA.
³ Department of Pediatrics, Stanford University, Stanford, California 94305, USA julsage@stanford.edu.
⁴ Department of Genetics, Stanford University, Stanford, California 94305, USA.

PMID: 37460156
PMCID: PMC10691483 (available on 2025-12-01)
DOI: 10.1101/cshperspect.a041383

Abstract

Cell division is obligatory to tumor growth. However, both cancer cells and noncancer cells in tumors can be found in distinct stages of the cell cycle, which may inform the growth potential of these tumors, their propensity to metastasize, and their response to therapy. Hence, it is of utmost importance to monitor the cell cycle of tumor cells. Here we discuss well-established methods and new genetic advances to track the cell cycle of tumor cells in mouse models of human cancer. We also review recent genetic studies investigating the role of the cell-cycle machinery in the growth of tumors in vivo, with a focus on the machinery regulating the G₁/S transition of the cell cycle.

Abstract

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