The spread of Chikungunya virus is a major public health concern in the Americas. There were >120,000 cases and 51 deaths in 2023, of which 46 occurred in Paraguay. Using a suite of genomic, phylodynamic, and epidemiologic techniques, we characterized the ongoing large chikungunya epidemic in Paraguay.
Keywords: ECSA lineage; East/Central/South African lineage; Paraguay; chikungunya virus; genomic monitoring; meningitis/encephalitis; rapid epidemic expansion; vector-borne infections; viruses.