Digging deeper into the early steps of cancer progression

Jonathan H Sussman; Ben Z Stanger

doi:10.1016/j.trecan.2023.07.003

Digging deeper into the early steps of cancer progression

Trends Cancer. 2023 Sep;9(9):703-704. doi: 10.1016/j.trecan.2023.07.003. Epub 2023 Jul 25.

Authors

Jonathan H Sussman¹, Ben Z Stanger²

Affiliations

¹ Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Graduate Group in Genomics and Computational Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
² Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: bstanger@upenn.edu.

PMID: 37495432
DOI: 10.1016/j.trecan.2023.07.003

Abstract

Epigenetically mediated cell signaling is emerging as a core principle of tumor biology. Through single cell multi-omic profiling, Burdziak, Alonso-Curbelo et al. have recently uncovered key epigenetic plasticity programs associated with cellular communication, shedding light on the role of epigenetic cell states during malignant transformation of the inflamed pancreas.

Publication types

Comment

MeSH terms

Cell Transformation, Neoplastic / genetics
Humans
Neoplasms* / genetics
Neoplasms* / pathology