Abstract
The pharmacokinetics of albendazole were investigated in healthy volunteers and in patients receiving albendazole for treatment of hydatid disease. Unchanged albendazole was below detectable limits in plasma, urine, bile and cyst fluid. The major metabolite present in all fluids was the sulfoxide. Maximum concentrations of albendazole sulfoxide in plasma were very variable, probably due to variable absorption of albendazole.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Absorption
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Adipose Tissue / metabolism
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Adult
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Albendazole
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Anthelmintics / blood
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Anthelmintics / metabolism*
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Anthelmintics / therapeutic use
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Benzimidazoles / blood
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Benzimidazoles / metabolism*
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Benzimidazoles / therapeutic use
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Echinococcosis / drug therapy
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Echinococcosis / metabolism
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Female
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Humans
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Kinetics
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Male
Substances
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Anthelmintics
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Benzimidazoles
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albendazole sulfone
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Albendazole
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albendazole sulfoxide