The role of cancer-associated fibroblasts in bladder cancer progression

Long Huang; Qun Xie; Jian Deng; Wen-Fei Wei

doi:10.1016/j.heliyon.2023.e19802

The role of cancer-associated fibroblasts in bladder cancer progression

Heliyon. 2023 Sep 4;9(9):e19802. doi: 10.1016/j.heliyon.2023.e19802. eCollection 2023 Sep.

Authors

Long Huang¹, Qun Xie¹, Jian Deng¹, Wen-Fei Wei^{2

3}

Affiliations

¹ Department of Urology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China.
² Department of Gynecology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China.
³ Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Abstract

Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. This review outlines the present knowledge of BCa CAFs, with a particular emphasis on their origin and function in BCa progression, and provides further insights into their clinical application.

Keywords: Bladder cancer; Cancer-associated fibroblasts; Chemotherapy resistance; Invasion and metastasis; Proliferation.

Publication types

Review