Methodical Manipulation of the TME in Ovarian Cancer

Clin Cancer Res. 2024 Jan 5;30(1):12-16. doi: 10.1158/1078-0432.CCR-23-2365.

Abstract

The complex interplay between ovarian cancer cells and the tumor microenvironment (TME) modulates progression, with dynamic cellular interactions influenced by external modulators, including neoadjuvant chemotherapy (NACT). A recent article described the alterations within the TME following NACT, either with or without bevacizumab, in ovarian cancer. See related article by Tavira et al., p. 176.

Publication types

  • Comment

MeSH terms

  • Bevacizumab / therapeutic use
  • Chemotherapy, Adjuvant
  • Cytoreduction Surgical Procedures
  • Female
  • Humans
  • Neoadjuvant Therapy
  • Ovarian Neoplasms* / drug therapy
  • Ovarian Neoplasms* / pathology
  • Retrospective Studies
  • Tumor Microenvironment*

Substances

  • Bevacizumab