Metastatic outgrowth via the two-way interplay of autophagy and metabolism

Amir Barzegar Behrooz; Marco Cordani; Massimo Donadelli; Saeid Ghavami

doi:10.1016/j.bbadis.2023.166824

Metastatic outgrowth via the two-way interplay of autophagy and metabolism

Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):166824. doi: 10.1016/j.bbadis.2023.166824. Epub 2023 Nov 9.

Authors

Amir Barzegar Behrooz¹, Marco Cordani², Massimo Donadelli³, Saeid Ghavami⁴

Affiliations

¹ Department of Human Anatomy and Cell Science, University of Manitoba College of Medicine, Winnipeg, Manitoba, Canada; Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
² Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain.
³ Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy.
⁴ Department of Human Anatomy and Cell Science, University of Manitoba College of Medicine, Winnipeg, Manitoba, Canada; Academy of Silesia, Faculty of Medicine, Rolna 43 Street, 40-555 Katowice, Poland; Department of Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada; Research Institute of Oncology and Hematology, Cancer Care Manitoba-University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: saeid.ghavami@umanitoba.ca.

PMID: 37949196
DOI: 10.1016/j.bbadis.2023.166824

Abstract

Metastasis represents one of the most dangerous issue of cancer progression, characterized by intricate interactions between invading tumor cells, various proteins, and other cells on the way towards target sites. Tumor cells, while undergoing metastasis, engage in dynamic dialogues with stromal cells and undertake epithelial-mesenchymal transition (EMT) phenoconversion. To ensure survival, tumor cells employ several strategies such as restructuring their metabolic needs to adapt to the alterations of the microenvironmental resources via different mechanisms including macroautophagy (autophagy) and to circumvent anoikis-a form of cell death induced upon detachment from the extracellular matrix (ECM). This review focuses on the puzzling connections of autophagy and energetic metabolism within the context of cancer metastasis.

Keywords: Autophagy; Cancer metastasis; Epithelial-mesenchymal transition; Extracellular vesicles; Metabolism; Tumor microenvironment; Wnt/β-catenin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autophagy
Humans
Neoplasms* / pathology
Proteins

Substances

Proteins