Analyzing the impact of metabolism on immune cells in tumor microenvironment to promote the development of immunotherapy

Yanru Long; Houhui Shi; Yuedong He; Xiaorong Qi

doi:10.3389/fimmu.2023.1307228

Analyzing the impact of metabolism on immune cells in tumor microenvironment to promote the development of immunotherapy

Front Immunol. 2024 Jan 8:14:1307228. doi: 10.3389/fimmu.2023.1307228. eCollection 2023.

Authors

Yanru Long¹, Houhui Shi¹, Yuedong He¹, Xiaorong Qi¹

Affiliation

¹ Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China.

Abstract

Tumor metabolism and tumor immunity are inextricably linked. Targeting the metabolism of tumors is a point worth studying in tumor immunotherapy. Recently, the influence of the metabolism of tumors and immune cells on the occurrence, proliferation, metastasis, and prognosis of tumors has attracted more attention. Tumor tissue forms a specific tumor microenvironment (TME). In addition to tumor cells, there are also immune cells, stromal cells, and other cells in TME. To adapt to the environment, tumor cells go through the metabolism reprogramming of various substances. The metabolism reprogramming of tumor cells may further affect the formation of the tumor microenvironment and the function of a variety of cells, especially immune cells, eventually promoting tumor development. Therefore, it is necessary to study the metabolism of tumor cells and its effects on immune cells to guide tumor immunotherapy. Inhibiting tumor metabolism may restore immune balance and promote the immune response in tumors. This article will describe glucose metabolism, lipid metabolism, amino acid metabolism, and immune cells in tumors. Besides, the impact of metabolism on the immune cells in TME is also discussed for analyzing and exploring tumor immunotherapy.

Keywords: amino acid metabolism; glucose metabolism; immunotherapy; lipid metabolism; metabolism reprogramming; tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Immunotherapy
Lipid Metabolism*
Stromal Cells
Tumor Microenvironment*

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Sichuan Province Tianfu Qingcheng Program Foundation, Grant/Award(No. KZ258) and Sichuan Science and Technology Program (No. 22ZDYF2119).