Association of adolescent postural tachycardia syndrome classifications with anxiety: a cross sectional study

Midori Mizutani; Seiji Yoshida; Hidetaka Tanaka; Ginroku Yamawake; Atsuko Kubo; Yusuke Kurooka; Yoshitaka Ohta; Akira Ashida

doi:10.1186/s13030-024-00301-z

Association of adolescent postural tachycardia syndrome classifications with anxiety: a cross sectional study

Biopsychosoc Med. 2024 Jan 29;18(1):2. doi: 10.1186/s13030-024-00301-z.

Authors

Midori Mizutani^{1

2}, Seiji Yoshida³, Hidetaka Tanaka⁴, Ginroku Yamawake², Atsuko Kubo², Yusuke Kurooka², Yoshitaka Ohta⁵, Akira Ashida²

Affiliations

¹ Department of Pediatrics, Hokusetsu General Hospital, Takatsuki, Japan.
² Department of Pediatrics, Osaka Medical and Pharmaceutical University Hospital, 2-7, Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.
³ Department of Pediatrics, Osaka Medical and Pharmaceutical University Hospital, 2-7, Daigakumachi, Takatsuki, Osaka, 569-8686, Japan. seiji.yoshida@ompu.ac.jp.
⁴ OD Hypotension Clinic Tanaka, Osaka, Japan.
⁵ Department of Pediatrics, Saiseikai Suita Hospital, Suita, Japan.

Abstract

Background: Postural tachycardia syndrome (POTS), a subset of orthostatic dysregulation, has been reported to be associated with anxiety. POTS can be classified into two forms based on the degree of tachycardia during orthostasis. Reportedly, POTS with decreased orthostatic heart rate increase is associated with suppressed cardiac parasympathetic activity and increased sympathetic activity in the supine position. In this study, the relationship between the two types of POTS and anxiety was evaluated in terms of autonomic function.

Methods: Fifty-two patients (23 male, age 10-15 years) who were diagnosed with POTS at the Department of Pediatrics, Osaka Medical and Pharmaceutical University from 2019 to 2021, completed a standing test and were accordingly classified into a Su group, with tachycardia from the supine position and a low heart rate increase on standing, a SI group, with a high heart rate increase during standing. They then completed the State-Trait Anxiety Scale for Children (STAIC) questionnaire. Autonomic function was assessed by frequency analysis (MemCalc method) based on heart rate, blood pressure changes, heart rate and blood pressure variability during the orthostatic test.

Results: Patients in the Su group had higher trait anxiety and state anxiety, lower cardiac parasympathetic activity (RR-HF) in the supine position, and greater variability in cardiac parasympathetic activity during orthostasis than were found for patients in the SI group. The Su group had a greater decrease in cardiac index on standing than that of the SI group.

Conclusions: The Su group results may be partly attributed to chronically low venous return. We also found that patients in the Su group had low parasympathetic activity in the supine position, which may interact with the anxiety-prone characteristics of these patients. Therefore, it seems necessary to consider both physical and psychosomatic treatment approaches for patients with POTS.

Keywords: Adolescent; Anxiety; Autonomic Function; Frequency analysis; POTS.