Efficient mitosis detection: leveraging pre-trained faster R-CNN and cell-level classification

Abstract

The assessment of mitotic activity is an integral part of the comprehensive evaluation of breast cancer pathology. Understanding the level of tumor dissemination is essential for assessing the severity of the malignancy and guiding appropriate treatment strategies. A pathologist must manually perform the intricate and time-consuming task of counting mitoses by examining biopsy slices stained with Hematoxylin and Eosin (H&E) under a microscope. Mitotic cells can be challenging to distinguish in H&E-stained sections due to limited available datasets and similarities among mitotic and non-mitotic cells. Computer-assisted mitosis detection approaches have simplified the whole procedure by selecting, detecting, and labeling mitotic cells. Traditional detection strategies rely on image processing techniques that apply custom criteria to distinguish between different aspects of an image. Additionally, the automatic feature extraction from histopathology images that exhibit mitosis using neural networks.Additionally, the possibility of automatically extracting features from histopathological images using deep neural networks was investigated. This study examines mitosis detection as an object detection problem using multiple neural networks. From a medical standpoint, mitosis at the tissue level was also investigated utilising pre-trained Faster R-CNN and raw image data. Experiments were done on the MITOS-ATYPIA- 14 dataset and TUPAC16 dataset, and the results were compared to those of other methods described in the literature.

Keywords: CNN; Faster R-CNN; MITOS-ATYPIA-14; mitosis; multiCNN.