SLC25A39 links mitochondrial GSH sensing with iron metabolism

Xiong Chen; Boyi Gan

doi:10.1016/j.molcel.2023.12.037

SLC25A39 links mitochondrial GSH sensing with iron metabolism

Mol Cell. 2024 Feb 15;84(4):616-618. doi: 10.1016/j.molcel.2023.12.037.

Authors

Xiong Chen¹, Boyi Gan²

Affiliations

¹ Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
² Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: bgan@mdanderson.org.

PMID: 38364779
DOI: 10.1016/j.molcel.2023.12.037

Abstract

Two recent studies by Liu et al.¹ in Science and Shi et al.² in this issue of Molecular Cell identify a mitochondrial GSH-sensing mechanism that couples SLC25A39-mediated GSH import to iron metabolism, advancing our understanding of nutrient sensing within organelles.

Publication types

Review

MeSH terms

Glutathione / metabolism
Iron* / metabolism
Mitochondria* / genetics
Mitochondria* / metabolism
Mitochondrial Membrane Transport Proteins*

Substances

Glutathione
Iron
SLC25A39 protein, human
Mitochondrial Membrane Transport Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding