1 Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
2 Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
3 Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Via di Grottarossa,1035-39, Rome 00189, Italy. Electronic address: giorgio.sesti@uniroma1.it.