Poised epigenetic states dictate metastatic fitness

Rebeka Tomasin; Cyrus M Ghajar

doi:10.1016/j.trecan.2024.03.001

Poised epigenetic states dictate metastatic fitness

Trends Cancer. 2024 Apr;10(4):275-276. doi: 10.1016/j.trecan.2024.03.001. Epub 2024 Mar 22.

Authors

Rebeka Tomasin¹, Cyrus M Ghajar²

Affiliations

¹ Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Center for Metastasis Research eXcellence (MET-X), Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
² Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Center for Metastasis Research eXcellence (MET-X), Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: cghajar@fredhutch.org.

PMID: 38521653
DOI: 10.1016/j.trecan.2024.03.001

Abstract

Seeking to define early events that regulate disseminated tumor cell (DTC) fate upon their arrival to the lung, Jakab et al. reach the surprising conclusion that dormancy is determined by a cell autonomous poised epigenetic state that renders DTCs responsive to angiocrine Wnt signaling.

Keywords: Wnt; dormancy; epigenetics; metastasis; niche; plasticity.

MeSH terms

Epigenesis, Genetic*
Humans