Abstract
Hamsters given the new penicillin temocillin, either orally or by injection, did not develop antibiotic-associated colitis, whereas animals given the control antibiotics cefoxitin or clindamycin developed the disease, which is characterized by marked hemorrhagic cecitis and high cecal levels of Clostridium difficile cytotoxin.
MeSH terms
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Administration, Oral
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Animals
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Anti-Bacterial Agents / toxicity*
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Cefoxitin / toxicity
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Clindamycin / toxicity
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Clostridium / isolation & purification
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Colitis / chemically induced*
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Cricetinae
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Feces / microbiology
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Gastrointestinal Hemorrhage / chemically induced
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Injections, Subcutaneous
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Mesocricetus
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Penicillins / toxicity*
Substances
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Anti-Bacterial Agents
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Penicillins
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temocillin
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Clindamycin
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Cefoxitin