Abstract
The authors investigated the pharmacological treatment of delusional depression by assigning patients on a random double-blind basis to amitriptyline alone, perphenazine alone, or a combination of the two. Fourteen (78%) of the 18 patients assigned to amitriptyline plus perphenazine were responders, compared with seven (41%) of 17 patients treated with amitriptyline alone and three (19%) of the 16 patients treated with perphenazine alone. The combination of amitriptyline and perphenazine was clearly superior (p less than .01).
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Amitriptyline / therapeutic use*
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Bipolar Disorder / complications
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Bipolar Disorder / drug therapy
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Bipolar Disorder / psychology
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Clinical Trials as Topic
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Delusions / complications
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Delusions / drug therapy*
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Delusions / psychology
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Depressive Disorder / complications
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Depressive Disorder / drug therapy*
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Depressive Disorder / psychology
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Double-Blind Method
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Drug Synergism
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Drug Therapy, Combination
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Female
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Hospitalization
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Humans
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Male
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Middle Aged
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Perphenazine / therapeutic use*
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Prospective Studies
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Psychiatric Status Rating Scales
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Random Allocation
Substances
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Amitriptyline
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Perphenazine