Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice

G M Martin; A C Smith; D J Ketterer; C E Ogburn; C M Disteche

Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice

Isr J Med Sci. 1985 Mar;21(3):296-301.

Authors

G M Martin, A C Smith, D J Ketterer, C E Ogburn, C M Disteche

PMID: 3997491

Abstract

Chromosomal aberrations were scored in the first metaphases of cells isolated from the kidneys of young (8 months old) and aged (40 months old) CB6F1 mice. There was a sixfold increase in the frequency of such aberrations in metaphases from old mice as compared with young mice.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aging*
Animals
Cells, Cultured
Chromosome Aberrations*
Karyotyping
Kidney / cytology*
Male
Metaphase
Mice
Mitotic Index

Abstract

Publication types

MeSH terms

Grants and funding