Abstract
Children with chronic diarrhea were examined for their carbohydrate tolerance, small bowel morphology, and specific disaccharidase activities to determine whether disaccharidase enzymatic activity is related to villus height and thus may be viewed as an independent variable that controls digestive capacity. Results indicated that 65-78% of all abnormal biopsy samples had specific disaccharidase activities that fell within the normal range. Clinical disaccharide tolerance studies indicated that specific enzyme activity did not correlate with disaccharide tolerance.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Child
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Child, Preschool
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Diarrhea / enzymology
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Diarrhea / etiology*
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Diarrhea / pathology
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Diarrhea, Infantile / enzymology
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Diarrhea, Infantile / etiology
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Diarrhea, Infantile / pathology
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Dietary Carbohydrates / adverse effects*
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Disaccharidases / metabolism*
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Humans
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Infant
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Intestinal Mucosa / enzymology
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Intestinal Mucosa / pathology
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Jejunum / enzymology
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Jejunum / pathology*
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Malabsorption Syndromes / complications
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Malabsorption Syndromes / diagnosis
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Malabsorption Syndromes / enzymology
Substances
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Dietary Carbohydrates
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Disaccharidases