In a prospective clinical study involving 458 diabetic patients, the results of noninvasive testing procedures were compared with the findings obtained by clinical evaluation. The results of the study showed that nearly one third of the patients who gave no history of intermittent claudication were found to have arterial disease when tested. One fifth of the patients with what were considered normal physical examination results had abnormal results by noninvasive testing. When history and physical examination prove ineffective for obtaining a diagnosis of arterial disease, the use of noninvasive devices effectively rules out or confirms the presence of hemodynamically significant arterial obstruction. Not only can simple, noninvasive testing methods greatly increase the accuracy of clinical diagnosis for the presence of arterial disease, but the baseline data obtained can serve as objective indexes to follow the natural history of the disease.