Abstract
ACNU was highly effective for Sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of ACNU for SLC showed clear dependence upon tumor size. Nonspecific activation of host-defence mechanism by Propionibacterium acnes contributed to the suppression for the regrowth of solid SLC treated by ACNU.
MeSH terms
-
Animals
-
Antineoplastic Agents / therapeutic use*
-
Lung Neoplasms / drug therapy
-
Lung Neoplasms / immunology
-
Lung Neoplasms / therapy*
-
Male
-
Neoplasms, Experimental / drug therapy
-
Neoplasms, Experimental / immunology
-
Neoplasms, Experimental / therapy*
-
Nitrosourea Compounds / therapeutic use*
-
Propionibacterium acnes*
-
Rats
Substances
-
Antineoplastic Agents
-
Nitrosourea Compounds