Abstract
Isolated rat brain tubulin can be repolymerized in vitro in solutions containing adenosine triphosphate or guanosine triphosphate, magnesium ions, and a good calcium chelator. The extreme sensitivity of tubulin to calcium ions explains the failure of previous efforts to obtain polymerization and suggests a possible mechanism for regulation of microtubule polymerization in vivo.
MeSH terms
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Adenosine Triphosphate / pharmacology
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Animals
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Brain / metabolism
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Calcium / pharmacology*
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Calcium Chloride / pharmacology
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Chelating Agents / pharmacology*
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Edetic Acid / pharmacology
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Guanosine Triphosphate / pharmacology
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In Vitro Techniques
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Magnesium Sulfate / pharmacology
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Microtubules / metabolism*
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Polymers
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Rats
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Tissue Extracts / metabolism
Substances
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Chelating Agents
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Polymers
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Tissue Extracts
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Magnesium Sulfate
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Guanosine Triphosphate
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Adenosine Triphosphate
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Edetic Acid
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Calcium Chloride
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Calcium