Abstract
Under group interaction in cats, a new Soviet tranquilizer mebicar eliminates fear-alarm induced by stimulatin of the emotiogenic zone of the hypothalamus. This action is not associated with myorelaxant or hypnotic action. Mebicar decreases the brain noradrenaline level, exerts no effect on the dopaminergic systems, increases the brain serotonin level, and does not elicit cholinolytic action.
MeSH terms
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Aggression / drug effects
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Animals
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Anti-Anxiety Agents / therapeutic use
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Anxiety / drug therapy*
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Behavior, Animal / drug effects*
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Biureas / pharmacology*
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Brain Stem / analysis
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Bridged Bicyclo Compounds / pharmacology*
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Bridged-Ring Compounds / pharmacology*
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Cats
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Diazepam / therapeutic use
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Dopamine / metabolism
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Emotions / drug effects*
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Fear / drug effects
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Galvanic Skin Response / drug effects
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Humans
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Mice
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Norepinephrine / analysis
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Parasympatholytics / pharmacology
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Psychotropic Drugs / pharmacology*
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Psychotropic Drugs / therapeutic use
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Rats
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Serotonin / analysis
Substances
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Anti-Anxiety Agents
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Biureas
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Bridged Bicyclo Compounds
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Bridged-Ring Compounds
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Parasympatholytics
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Psychotropic Drugs
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mebikar
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Serotonin
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Diazepam
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Dopamine
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Norepinephrine