Abstract
Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.
MeSH terms
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Anti-Anxiety Agents / adverse effects*
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Anti-Anxiety Agents / metabolism
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Anti-Anxiety Agents / therapeutic use
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Benzodiazepines / adverse effects
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Benzodiazepines / therapeutic use
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Flurazepam / therapeutic use
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Half-Life
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Humans
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Midazolam
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Sleep / drug effects
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Sleep Initiation and Maintenance Disorders / drug therapy
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Sleep Initiation and Maintenance Disorders / etiology*
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Triazolam / adverse effects
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Triazolam / therapeutic use
Substances
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Anti-Anxiety Agents
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Benzodiazepines
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Triazolam
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Flurazepam
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quazepam
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Midazolam